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Apcalis Tablets and Oral Jellies work in much the same way as Kamagra, except the effects last much longer (typically 24-36 hours) As with Kamagra, Apcalis is also a PDE-5 inhibitor. Similar precautions should also be taken before taking Apcalis Tablets and Oral Jelly (see precautions before taking Apcalis). Apcalis should not be taken more than once a day. Daily use of Apcalis is not recommended.

How it works?
The arteries that feed the spongy tissue in the penis dilate when they receive signals from the brain. The signal is carried by nitric oxide in the blood. It switches on the enzyme which makes a molecule known as cGMP (cyclic Guanosine Monophosphate). This triggers smooth muscle in the artery wall to relax and so the blood vessel dilates . However, the cGMP is broken down by another enzyme known as PDE (Phosphodiesterase) causing the arteries to narrow again - bringing an end to the erection. Kamagra™ inhibits the PDE and stops it from breaking down the cGMP. In this way, the natural erection is maintained. It doesn't last forever - only as long as the natural stimulation remains.

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